Extended Data Fig. 10: S-ISR gene expression alterations are distinct from those observed during other stress conditions. | Nature

Extended Data Fig. 10: S-ISR gene expression alterations are distinct from those observed during other stress conditions.

From: Plasticity of the mammalian integrated stress response

Extended Data Fig. 10

(a-c) (Left), Scatter plots from anota2seq analysis of shEif2b5 versus control cells (left panels) wherein genes whose expression was identified as induced (orange) or suppressed (red) following (a) ER stress (polysome-profiling)43, (b) mitochondrial stress (proteomics)44 or (c) oxygen and glucose deprivation (ribosome profiling)42 are indicated together with genes showing unaltered expression (background in grey). (Middle and Right) empirical cumulative distribution function (ECDF) plots of log2fold-changes (log2FC) from the sheIF2Bε versus control comparison for polysome-associated mRNA (middle panels) and total RNA (right panels) for stress-sensitive gene sets and background genes (grey). Significant shifts in the distribution of gene sets relative to the background were assessed using a two sided Wilcoxon rank-sum test and p-values are indicated.

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