Fig. 1: Detection of heat and differential tuning of somatosensory neuron classes.
From: A distributed coding logic for thermosensation and inflammatory pain
a, Heat maps showing in vivo GCaMP responses from 1,588 transcriptomically classified neurons from 15 mice tested with mechanical stimulation and heat. Heat maps are grouped by neuronal class with changes in GCaMP fluorescence (% ΔF/F) colour-coded as indicated by the scale bar. b, Proportions of heat (red), polymodal (orange) and mechanically tuned neurons (grey) for each class; the number of neurons and mice used for assignment are indicated. c, Mean responses of heat-responsive nociceptors by class (solid trace; numbers of heat-responsive cells indicated); the shaded area represents 95% confidence interval. d, Fractional recruitment of cheek-responsive neurons by class and temperature. e, Fractional representation of heat responses by class across the temperature range. Colour coding is as in d with LTMRs in grey; numbers of mice and cells are detailed in Supplementary Table 1. Scale bars, 10 s.
