Extended Data Fig. 5: Inflammatory heat sensitization and sensory stimulus ongoing activity of nociceptors in wild type mice.
From: A distributed coding logic for thermosensation and inflammatory pain
a) Response magnitude (mean AUC ± s.e.m) at the holding temperature of 30 °C (No stimulus) and at 45 °C before (light or dark grey) and after PGE2 injection (pink or red) expose the relative contributions of ongoing activity and thermal sensitization that occur in this model of inflammatory pain. There was a significant increase in the magnitude of the temperature response (response at 45 °C minus response without stimulation) in PEP and NP2A nociceptors after PGE2 induced inflammation. (b) Heat response magnitude (mean AUC ± s.e.m) for wild type mice before (grey) and after (red) PGE2 injection to the cheek. p < 0.05, *; p < 0.01, **; p < 0.001, ***; for details of statistical tests and numbers of mice and cells see Supplementary Information, Tables 1 and 2.
