Fig. 2: In vivo functional imaging of Cre lines confirmed that NP1 and NP2B neurons detect noxious mechanical and thermal stimuli. | Nature

Fig. 2: In vivo functional imaging of Cre lines confirmed that NP1 and NP2B neurons detect noxious mechanical and thermal stimuli.

From: A distributed coding logic for thermosensation and inflammatory pain

Fig. 2: In vivo functional imaging of Cre lines confirmed that NP1 and NP2B neurons detect noxious mechanical and thermal stimuli.

a, Heat maps showing calcium transients from Ai95 carrying knock-in alleles to label NP1 (upper panel; 561 neurons; four mice) and NP2B (lower panel; 72 neurons; three mice) neurons. Changes in GCaMP fluorescence in response to stimuli applied to the cheek are colour-coded by % ΔF/F (inset scale). b,c, Percentage of neurons (mean ± s.e.m.) responding to each stimulus for cells identified by ISH after functional imaging (pale grey) or Cre-mediated labelling (dark grey). b, NP1 cells: ISH, n = 13; CreER, n = 4. c, NP2B cells: ISH, n = 12; tdT, n = 3. See Supplementary Table 2 for details and statistics. Scale bar, 10 s.

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