Extended Data Fig. 10: Comparison of EV-D68 receptor binding with other enterovirus ligands. | Nature

Extended Data Fig. 10: Comparison of EV-D68 receptor binding with other enterovirus ligands.

From: MFSD6 is an entry receptor for enterovirus D68

Extended Data Fig. 10

Asymmetric units of ligand-bound enteroviruses for structural comparison. A legend shows colourings for enterovirus capsid proteins, with VP1 in light purple, VP2 in light green, and VP3 in light red. Residues within a 4 Å interaction radius are shown in bright purple, green, and red surfaces, respectively. VP4 (behind) is not visible in this view. Ligand-bound enteroviruses include (a) RV-B14 and ICAM-1 (PDB ID: 7BG7); (b) EV-D68 and Fc-MFSD6(L3), in which the interaction involves Fc-MFSD6(L3) chains E-F but chain F is removed for clarity; (c) EV-D68 and sialic acid (PDB ID: 5BNO); (d) EV-D68 and 8F12 Fab (PDB ID: 7EC5); (e) EV-D68 and 2H12 Fab (state S1) (PDB ID: 7EBZ); and (f) EV-D68 and EV68-228 Fab (PDB ID: 6WDT). Ligands are shown in yellow (b-c) or transparent orange (a, d-f).

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