Extended Data Fig. 12: AtrxKO expression signature is associated with loss of HNF4A activity. | Nature

Extended Data Fig. 12: AtrxKO expression signature is associated with loss of HNF4A activity.

From: Loss of colonic fidelity enables multilineage plasticity and metastasis

Extended Data Fig. 12: AtrxKO expression signature is associated with loss of HNF4A activity.The alternative text for this image may have been generated using AI.

Heatmap of z-scores of ATAC-seq log2 normalised counts across 77 samples from 37 CRC patients from the TCGA. ATAC-seq peaks shown correspond to the significantly differential accessible regions in patients with high AtrxKO expression score vs high AtrxWT patients. FDR was calculated using two tailed ttest.

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