Extended Data Fig. 1: The yields of ΨGA codons within targeted mRNAs under different dosage of gsnoRNA and PylRS-tRNAPyl. | Nature

Extended Data Fig. 1: The yields of ΨGA codons within targeted mRNAs under different dosage of gsnoRNA and PylRS-tRNAPyl.

From: RNA codon expansion via programmable pseudouridine editing and decoding

Extended Data Fig. 1: The yields of ΨGA codons within targeted mRNAs under different dosage of gsnoRNA and PylRS-tRNAPyl.

a-c, The IGV views and ΨGA codon yields within three targeted reporters: LDLR-TGA (a), AGXT-TGA (b), and Screen-TGA (c) at 0%, 25%, 50%, and 100% of the corresponding guide snoRNA. d, The IGV views and ΨGA codon yields within targeted Screen-TGA reporter under zero, 1:1, 1:4 or 1:8 stoichiometry to PylRS-tRNAPyl. Data of bar plots are presented as the mean values (n = 2 biologically independent replicates).

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