Extended Data Table 3 In vitro ADME and toxicology profile for JNJ-6640

From: Targeting de novo purine biosynthesis for tuberculosis treatment

  1. m: mouse; h: human; r: rat. ACA: cytotoxicity; Glu/Gal: mitotoxicity; AMES: genotoxicity; hERG: cardiotoxicity; Papp (A-B): permeability; LM Clint: liver microsome intrinsic clearance; Hep Clint: hepatocyte intrinsic clearance; CYP IC50: inhibition of cytochrome p450 enzymes.
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