Extended Data Fig. 7: Single-cell transcriptomic landscape of the TME in anti-PD1 and anti-TL1A treated tumors.
(a) t-SNE projection showing distribution of all cells colored by treatment condition (dark grey, PBS; orange, anti-PD1; blue, anti-PD1 and anti-TL1A). (b) t-SNE plot of all cells colored by expression of genes supporting cell-type assignments. (c, d, e) Bar plot showing frequency of CD4 T cells (c), NK cells (d), and myeloid cells (e) within clusters of interests in different treatment group. (f) Related to Fig. 4j,k. Flow cytometry gating strategies for CD8 T cells. Antibodies used for staining were listed in the methods.
