Extended Data Fig. 4: Longitudinal changes of the abundance of CD8⁺ T cells and NK cells in PPP2R1A mutant and wildtype samples.

a-d. Longitudinal changes of the absolute proportion of CD8⁺ T cells (a), activated NK cells (b), resting NK cells (c) and total NK cells (d) in all samples from PPP2R1A-mutant and WT cases. e-h. Longitudinal changes of the absolute proportion of CD8⁺ T cells (e), activated NK cells (f), resting NK cells (g) and total NK cells (h) in paired samples from PPP2R1A-mutant and WT cases. In box plots, the centre line represents the median value; the lower and upper hinges correspond to the first and third quartiles, respectively; the whiskers represent 1.5 × interquartile ranges. For panels a-d, P values were calculated using two-sided Wilcoxon rank sum tests. For panels e-h, P values were calculated using two-sided Wilcoxon signed rank tests.