Extended Data Fig. 7: Tumor cell phenotypes in the context of WGD and mutation signatures.
From: Ongoing genome doubling shapes evolvability and immunity in ovarian cancer
a. Scatter plot depicting regression coefficients (x-axis) and significance (y-axis) for selected genes and pathways in WGD-high vs WGD-low tumor cells in the HRD-Dup mutation signature subset. b. Violin plots of per-sample mean expression for select cancer-cell-intrinsic signaling pathways faceted by mutation signature subset and WGD status: FBI (WGD-low n = 3 samples, WGD-high n = 27 samples), HRD-Del (WGD-high n = 17 samples), and HRD-Dup (WGD-low n = 31 samples, WGD-high n = 16 samples). Dot indicates median and bars indicate quartiles. c. Dotplot of correlations between missegregation rates derived from scWGS (column) and cancer-cell-intrinsic pathways from scRNA-seq in site-matched samples (row). Spearman’s rho significance is annotated as ‘ns’: 5.0 × 10-2 <p <= 1, ‘*’: 1.0 × 10−2 < p <= 5.0 × 10−2, ‘**’: 1.0 × 10−3 < p <= 1.0 × 10−2, ‘***’: 1.0 × 10−4 < p <= 1.0 × 10−3, ‘****’: p <= 1.0 × 10−4.
