Fig. 4: Modes of evolution post WGD.
From: Ongoing genome doubling shapes evolvability and immunity in ovarian cancer
a, Pre- and post-WGD events illustrated for the ancestral branch of patient OV-044. Top, CN profile of the inferred ancestral non-WGD clone. Bottom, CN profile of the WGD clone. The plots in between show the CN changes (positive indicating gains, negative indicating losses) inferred to be pre-WGD and post-WGD, as illustrated on the left. b, Counts of ancestral arm and chromosome events detected across the cohort for non-WGD ancestral branches of WGD-low tumours, and pre- and post-WGD branches for WGD-high tumours. Bars and 95% confidence intervals show the distribution of counts on the given type of branch. Mann–Whitney U-test significance (FDR corrected) is annotated as: *1.0 × 10−2 < P ≤ 5.0 × 10−2, **1.0 × 10−3 < P ≤ 1.0 × 10−2, ***1.0 × 10−4 < P ≤ 1.0 × 10−3, ****P ≤ 1.0 × 10−4. Only significant comparisons are shown. c, Bar plots show counts of arm and chromosome events occurring post-WGD for all high-confidence clonal and subclonal WGD events detected across the cohort, split by clonality of the WGD (cell fraction threshold, 0.99). Bars and 95% confidence intervals show the distribution of counts on the root branch of the given type of WGD. Each bar indicates a clone that is labelled below and annotated above with the number of WGD events ancestral to the clone, as well as its clonality. The bottom bar plots show the fraction of cells from each patient that the clone represents. d, Boxplots summarizing c, annotated with FDR-corrected significance (Mann–Whitney U-test) as in b. NS, not significant.
