Extended Data Fig. 2: Cancer-induced nerve injury (CINI) in a metastatic disease model.
From: Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy
Gene expression of c-Jun and Atf3 in the jugular-nodose ganglia neurons from mice with melanoma lung metastases (B16F10-OVA) was compared to PBS vehicle controls. Each dot represents an independent biological sample, with n = 3 for each group. The box plots illustrate the median (centre line), the 25th and 75th percentiles (box bounds), and the minimum and maximum values (whiskers). P-values (FDR) were calculated using the empirical Bayes quasi-likelihood F-test implemented in edgeR and were corrected for multiple hypothesis testing using the Benjamini–Hochberg method.
