Extended Data Fig. 10: Genetic inactivation of Sarm1 results in more diffuse tumours in a second independent mouse model.
From: Axonal injury is a targetable driver of glioblastoma progression
a, Tumour cell density in terminal npp tumours generated in wild-type (grey, WT) or Sarm1-/- (turquoise) mice plotted against survival. Circles indicate localized tumours; triangles indicate diffuse tumours. No correlation is found between tumour density and survival in either genotype. Two-sided Pearson correlation R. Regression line with 95% confidence interval per genotype. n = 10 for WT, n = 9 mice for Sarm1-/-. b, Survival curves of WT tumours stratified on localized or diffuse histology. Mean ± SD survival for WT mice with a localized or diffuse tumour were 112 ± 12 and 112 ± 14, respectively. n = 11 for localized tumours and n = 9 mice for diffuse tumours. c, Representative fluorescence images of npp tumours generated in Sarm1em1.1Tftc and genetic background matched Sarm1wt mice (WT). Images show tdTomato+ tumour cells (red) and nuclei are counterstained with DAPI (blue). Scale bar=1 mm. d, Quantification of number of tumour cells per mm2 in tumours shown in c. Mean ± SD. Two-sided unpaired t test. n = 4 mice for both genotypes. p = 0.042.
