Fig. 5: Blunted MeA→VMH neuron activation with chronic stress promotes weight gain and hyperglycaemia.
From: Amygdala–liver signalling orchestrates glycaemic responses to stress
a, GCaMP8s z-scores in a MeAVMH axon before, during and after repeated 2 min territorialized cage stress (red bar). b, GCaMP8s z-scores in MeAVMH axons aligned to the start of each territorialized cage exposure. c, Mean axon GCaMP8s z-score for each exposure period. d, Blood glucose before and after each repeated 2 min territorialized cage stress. e, Quantification of MeA FOS+ cells with 1, 8 or 9 exposures to 30 min of restraint stress or unstressed mice, with timeline of the chronic stress regime. f, Blood glucose before and after the first and last 30 min restraint sessions in the chronic stress regime. g, Schema for chronic silencing of the MeA–VMH circuit. h, Blood glucose in mice treated as depicted in g with 30 min of restraint stress. i,j, Body weight (i) and fed blood glucose (j) in mice treated as depicted in g on low fat (chow) diet (LFD). k–m, Body weight (k), fed blood glucose (l) and blood glucose during GTT (m) in mice treated as depicted in g on high-fat diet (HFD). n,o, Relative expression of adrenergic receptor (n) and gluconeogenic (o) genes in mice treated as depicted in g, on a high-fat diet. Data are mean ± s.e.m. Individual data points represent individual mice. Sample size and statistical analysis in Supplementary Data Table 1.
