Extended Data Fig. 9: Hotspot gene modules across adult datasets.
From: Conservation and alteration of mammalian striatal interneurons
To further examine the relationship between the terminal classes across species, we projected gene co-expression modules that mark interneuron populations in one species onto other species using Hotspot29. Non-overlapping gene modules were discovered in each species, and the modules with the highest correlations to individual marker genes were selected for cross-species projection (Supplementary Table 1; see Methods). Marker genes are also plotted for reference. The species in which the module was discovered is always plotted on the left. a,b, Mouse Chat and Sst modules showed strong enrichment in the corresponding primate cell types. c–f, Human and marmoset CHAT and SST modules showed strong enrichment in the corresponding cell types across species. g,h, Mouse Tac2 and Th modules showed enrichment in primate Tac3 clusters, but with variable selectivity. i–l. Marmoset and human TAC3 modules (i,k) showed enrichment in primate TAC3 clusters and expression in mouse Th and Sst/Npy clusters, while Marmoset and human TH clusters (j,l) showed enrichment in mouse PTHLH/PVALB, supporting a distinction between primate and rodent TH populations.
