Extended Data Fig. 10: Comparison of adult inhibitory neuron terminal classes.

a. Schematic demonstrating the cross-species scVI integration workflow, starting with how striatal inhibitory interneurons were identified and annotated from previously unlabelled marmoset HMBA data (see Methods). b. Integrated UMAP embeddings coloured by clusters for each primate species. New labels from HMBA Basal Ganglia taxonomy (from taxonomy’s “Group” level) are grey in far right panel. c. Dot plot showing the adult mouse cells from the ABC, now with the inclusion of CCK-expressing types which were detected in striatal dissections but annotated as cortical. This Cck type was predominantly annotated as class 06 CTX-CGE GABA subclass 049 Lamp5 Gaba, and Cck/Vip was predominantly class 06 subclass 046 Vip Gaba. d. Integrated UMAP embedding coloured by LHX8/Lhx8 expression in each species. Small numbers of LHX8-expressing TAC3 types from Krienen et al. and Siletti et al. datasets co-embed with the HMBA TAC3/LHX8 cluster. e. SAMap homology as in Fig. 4, but using marmoset HMBA data. f. Abundance of the TAC3 type in each species, shown as a cell count ratio to each of the other major inhibitory interneuron types.