Fig. 3: The MGE_CRABP1/TAC3 initial class is modified in rodents to express Th.
From: Conservation and alteration of mammalian striatal interneurons
a, Schematic of experimental design. b, UMAP coloured by inhibitory neuron initial classes recovered from the MGE, LGE and striatum of developing mice. c, Heat map of selected initial class markers, scaled and normalized. d, UMAP coloured by markers of Lhx6/Crabp1-expressing initial classes, scaled and normalized. Top row contains markers of MGE_CRABP1/MAF; bottom row contains markers of MGE_CRABP1/TAC3. e, Pearson correlation based on PCA of mouse MGE_CRABP1 initial classes to integrated classes for all species except mice. f, Marker-gene expression in Glires from the integrated MGE_CRABP1/TAC3 cluster, scaled and normalized. g, High-magnification (100×) maximum intensity projection of tdTomato reporter expression and RNAscope of markers Crabp1 and Th in the E17 Nkx2-1-Cre;Ai14 mouse brain. Arrowheads indicate the MGE_CRABP1/TH initial class. Scale bar, 25 μm. h, High-magnification (100×) maximum intensity projection of RNAscope with markers Lhx6, Crabp1 and Th in the adult rat striatum. Arrowheads indicate the MGE_CRABP1/TH initial class. Scale bar, 25 μm.
