Extended Data Fig. 2: Survey of inhibitory neuron initial classes in the developing macaque, rat and rabbit brain.
From: Conservation and alteration of mammalian striatal interneurons
a. UMAP coloured by inhibitory initial classes in developing macaque scRNA-seq data from Schmitz et al.6. (n = 109,111 inhibitory neurons). b. Heat map of selected markers of inhibitory initial class markers, scaled and normalized. c. UMAP coloured by markers of MGE_CRABP1 initial classes, scaled and normalized. d. Slingshot pseudotime calculation. e. Reconstruction of lineage trajectories with circles visualizing cell-type connections calculated using Slingshot. f. UMAP coloured by inhibitory neuron initial classes in the E18 developing rat brain (n = 35,923 inhibitory neurons). g. UMAP coloured by region of dissection. h. Heat map of selected markers of inhibitory initial class markers, scaled and normalized. Bar plot indicates proportion of cells from cortical and striatal dissection in each initial class. i. UMAP coloured by markers of MGE_CRABP1 initial classes, scaled and normalized. j. Slingshot pseudotime calculation. k. Reconstruction of lineage trajectories with circles visualizing cell-type connections calculated using Slingshot. l. UMAP coloured by inhibitory neuron initial classes in the E23 developing rabbit brain (n = 36,580 inhibitory neurons. m. UMAP coloured by region of dissection. n. Heat map of selected markers of inhibitory initial class markers, scaled and normalized. Bar plot indicates proportion of cells from cortical and striatal dissection in each initial class. o. UMAP coloured by markers of MGE_CRABP1 initial classes, scaled and normalized. p. Slingshot pseudotime calculation. q. Reconstruction of lineage trajectories with circles visualizing cell-type connections calculated using Slingshot.
