Extended Data Fig. 5: Comparison between three representative designed channels and native channels, as well as the closest structures in the PDB (by Foldseek).
From: Bottom-up design of Ca2+ channels from defined selectivity filter geometry
CalC4_24 was compared with TRPV6 (PDB 6BO8), CalC6_3 was compared with Orai (PDB 7KR5), and CalC6_H4 was compared with connexin 26 (PDB 2ZW3) from the top (a, d, and g) and the side view (b, e, and h), respectively. c, f, and i, Overlay of CalC4_24 (c), CalC6_3 (f), and CalC6_H (i) and their closest structures in the PDB (3zci in c, TM Score=0.35; 8d9p in f, TM Score=0.48; 6z0c in i, TM Score=0.41).
