Extended Data Fig. 9: Down-regulation of collagen gene expression in fibroblast and basal-myoepithelial subclusters following UA treatment.
From: Anti-progestin therapy targets hallmarks of breast cancer risk
Boxplots of down-regulated collagens in BMYO1, FB1, FB2 and FB3 subclusters showing gene expression across participant samples at baseline and post-treatment. Box plots centre lines represent median values, box bounds indicate the 25th and 75th percentiles, and whiskers extend to the most extreme datapoint within 1.5 × IQR (inter-quartile range) of the outer hinge of the boxplot. P-value and log fold change (post-treatment/baseline) determined using Memento are overlaid. Memento significance is calculated using a nonparametric permutation test where observed mean differences are compared to a null distribution generated by permuting treatment group labels. N = 6 tissue pairs.
