Extended Data Fig. 7: Conformational states of the PS-bound GluN1a-2B NMDAR.
From: Mechanism of conductance control and neurosteroid binding in NMDA receptors
The structure of the PS-bound structures in the non-active and pre-active states viewed from the side (upper panels) and top (lower panels) of the TMDs. The pre-active state shows a greater distance between the GluN2B Gln662 residues compared to the non-active state due to the GluN1a-2B LBD dimer rotations (curved arrows). In both cases, the channel gate remains closed. The hydrophobic gate residues are shown as magenta (GluN1) and deep teal (GluN2B) spheres.
