Fig. 3: Characterization of variance explained by trait-associated variants detected in WGS-based GWAS.
From: Estimation and mapping of the missing heritability of human phenotypes
a, Proportion of WGS-based heritability explained by trait-associated variants. Left bars compare the variance explained by RVAs relative to the estimated heritability attributable to rare variants. Right bars compare the variance explained by CVAs relative to the estimated heritability attributable to common variants. Vertical dashed lines represent average proportions across phenotypes. b, Distribution of variance explained by RVAs as a function of the distance to nearest common variant. The P value shown at the top-left corner of the panel is based on a two-sided F-test with 2 and 879 degrees of freedom. Here, n denotes the number of RVAs in the corresponding annotation. A few RVAs were further annotated with the corresponding trait and the closest gene. The boxplots shown here represent the first quartile, the median and the third quartile of the corresponding distribution. c, Average of density of CVA within an increasing window size (x axis) around each RVA. Error bars represent s.e.s.
