Extended Data Fig. 2: Effect of assortative mating (AM) on heritability estimates.
From: Estimation and mapping of the missing heritability of human phenotypes
(a) Comparison between GREML (x-axis) and HE-based estimates (y-axis). Outlier traits are height (HT) and educational attainment (EA), consistent with prior evidence of AM on these traits and the fact that AM affects differently GREML and HE estimates. (b) Comparison of pedigree-, HE-, and GREML-based estimates for HT and EA. For pedigree-based estimates AM-adjusted means that the estimate was converted from that in a population under AM-equilibrium to an expected value under random mating. For HE-regression estimates, “AM-adjusted” means that the estimates were corrected for AM-induced biased using the formula proposed by Border et al.25. AM-adjustment assumes a spousal correlation of 0.2 for height and 0.4 for EA. Error bars represent standard errors.
