Table 1 Summary of pedigree-based estimates of heritability \({\boldsymbol{(}}{\hat{{\boldsymbol{h}}}}_{{\bf{P}}{\bf{E}}{\bf{D}}}^{{\bf{2}}}{\boldsymbol{)}}\) and WGS-based estimates of heritability \({\boldsymbol{(}}{\hat{{\boldsymbol{h}}}}_{{\bf{W}}{\bf{G}}{\bf{S}}}^{{\bf{2}}}{\boldsymbol{)}}\) for 34 phenotypes

From: Estimation and mapping of the missing heritability of human phenotypes

Phenotype

Acronym

\({\hat{{\boldsymbol{h}}}}_{{\bf{P}}{\bf{E}}{\bf{D}}}^{{\bf{2}}}\)

s.e. (\({\hat{{\boldsymbol{h}}}}_{{\bf{P}}{\bf{E}}{\bf{D}}}^{{\bf{2}}}\))

\({\hat{{\boldsymbol{h}}}}_{{\bf{W}}{\bf{G}}{\bf{S}}}^{{\bf{2}}}\)

s.e. (\({\hat{{\boldsymbol{h}}}}_{{\bf{W}}{\bf{G}}{\bf{S}}}^{{\bf{2}}}\))

P

Albumin

ALB

0.277

0.031

0.243

0.010

0.299

Alkaline phosphatase

ALK

0.435

0.026

0.420

0.009

0.572

Alanine aminotransferase

ALT

0.148

0.029

0.190

0.010

0.156

Heel bone mineral density

BMD

0.375

0.035

0.396

0.014

0.591

BMI

BMI

0.392

0.023

0.339

0.009

0.031

Chronic ischaemic heart disease (I25)

CIHD

0.300

0.113

0.228

0.026

0.539

Creatinine

CREA

0.244

0.028

0.295

0.009

0.077

C-reactive protein

CRP

0.178

0.030

0.138

0.010

0.203

Diastolic blood pressure

DBP

0.171

0.029

0.211

0.010

0.191

Dyslipidaemia (E78)

DISLIP

0.350

0.080

0.216

0.018

0.101

Educational qualification

EA

0.409

0.015

0.347

0.009

<0.001

Forced expiratory volume in 1 s

FEV1

0.313

0.033

0.299

0.011

0.689

Fluid intelligence score

FI

0.405

0.036

0.328

0.027

0.084

Hand grip strength

GRIP

0.310

0.028

0.223

0.009

0.003

Haemoglobin concentration

Hb

0.272

0.028

0.272

0.009

0.987

HDL cholesterol levels

HDL

0.541

0.029

0.398

0.009

<0.001

Standing height

HT

0.882

0.010

0.709

0.006

<0.001

Hypertension (I10)

HypT

0.251

0.070

0.253

0.015

0.986

IGF-1

IGF

0.405

0.028

0.354

0.009

0.083

LDL cholesterol levels

LDL

0.239

0.029

0.228

0.010

0.705

Mean corpuscular volume

MCV

0.509

0.027

0.413

0.008

<0.001

Number of children

NC

0.152

0.028

0.075

0.010

0.010

Neuroticism score

NEURO

0.212

0.034

0.185

0.011

0.455

Platelet count

PLAT

0.554

0.027

0.457

0.008

<0.001

Red blood cell count

RBC

0.388

0.027

0.355

0.009

0.251

Systolic blood pressure

SBP

0.188

0.029

0.217

0.010

0.333

Sleep duration

SLP

0.106

0.028

0.125

0.009

0.523

Ever smoked

SMK

0.248

0.060

0.174

0.015

0.237

Type 2 diabetes (E11)

T2D

0.597

0.100

0.403

0.030

0.065

Telomere length

TELO

0.377

0.028

0.127

0.010

<0.001

Triglycerides levels

TG

0.323

0.029

0.287

0.009

0.240

Vitamin D

VITD

0.227

0.030

0.178

0.010

0.118

White blood cell count

WBC

0.319

0.028

0.324

0.009

0.864

Waist-to-hip ratio

WHR

0.291

0.027

0.240

0.009

0.071

  1. Standard errors are denoted as s.e. and P values comparing \({\hat{h}}_{{\rm{P}}{\rm{E}}{\rm{D}}}^{2}\) with \({\hat{h}}_{{\rm{W}}{\rm{G}}{\rm{S}}}^{2}\) as P. P values were conservatively derived from a two-sided Wald test. ICD10 codes for diseases are indicated between brackets following the phenotype name. We report here P values lower than 0.001 for EA (6.06 × 10−4), HDL (2.50 × 10−6), HT (3.30 × 10−45), MCV (7.94 × 10−4), PLAT (5.74 × 10−4) and TELO (3.02 × 10−17). Pedigree-based estimates for HT, educational attainment and fluid intelligence are adjusted for assortative mating as described in Extended Data Fig. 2 and Supplementary Table 6.
Back to article page