Fig. 4: Divergent late-stage functionalizations via radical deamination.
From: Deaminative cross-coupling of amines by boryl radical β-scission
a, Late-stage functionalization of sertraline 1x. Yields reported for products 4q and 5k are from intermediate 6g. b, Late-stage functionalization of rivastigmine 1y. Yields reported for products 4r, 5m and 5n are from intermediate 6k. c, Late-stage functionalization of dapoxetine 1z. d, Diversification of the alkyl side chain of cinacalcet 1aa. Yields reported for products 4t, 5o and 5p are from intermediate 6o. e, Use of deaminative couplings on lactam 1ab. Yields reported for products 4u–4w and 3t are from intermediate 6d. See Supplementary Information for specific reaction conditions for the divergent functionalization. Ar, 1-naphthyl.
