Extended Data Fig. 7: Mitochondrial alterations in brain sections of 5xFAD mouse model at different stages of AD pathogenesis. | Nature

Extended Data Fig. 7: Mitochondrial alterations in brain sections of 5xFAD mouse model at different stages of AD pathogenesis.

From: iPEX enables micrometre-resolution deep spatial proteomics via tissue expansion

Extended Data Fig. 7: Mitochondrial alterations in brain sections of 5xFAD mouse model at different stages of AD pathogenesis.The alternative text for this image may have been generated using AI.

a, IF images showing expression and localization of the Tom20 protein in mouse brain sections of WT and 5x FAD at 2-, 6-, and 8-mo of ages. b, Fluorescence images of 10-mo wild-type and 5x FAD mouse brains following live-tissue PK-mito-red staining. c, Fluorescence images of 2-mo wild-type and 5x FAD mouse brains following live-tissue PK-mito-red staining. d, Fluorescence images of 12-mo wild-type and 5x FAD mouse brains following live-tissue PK-mito-red staining. e, Fluorescence images of 5-mo wild-type and 5x FAD mouse brains following intracerebral injection of pAAV-Ascl1-CAGdMito2-COX8-mBaoJin. f, Transmission electron microscope (TEM) images showing the ultrastructures of brain tissues in WT and 5xFAD brain tissues at different ages including mitochondrial morphologies in the fibre tracts (top) and hippocampus (bottom) regions. Scale bars indicated in images.

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