Extended Data Fig. 10: Long-segmental copy number changes in breast cancer.

Relative molecular timing of recurrent copy number amplifications (CNAs). From top to bottom: number of patients harboring each CNA; percentage of PAM50; integrative clusters (IntClust) molecular subtypes among samples with the respective CNA; box plots indicating median (middle line), first and third quartiles (edges) and 1.5x the interquartile range (whiskers); hazard ratio estimates with 95% confidence intervals; violin plots displaying the distribution of relative CNA timing (black dots represent the mean timing); and the G-score from GISTIC algorithm.