Extended Data Fig. 10: Working model of neutrophil-derived IL-1β regulating lipolysis during β3-adrenergic stimulation. | Nature

Extended Data Fig. 10: Working model of neutrophil-derived IL-1β regulating lipolysis during β3-adrenergic stimulation.

From: Neutrophils preserve energy storage in sympathetically activated adipocytes

Extended Data Fig. 10

β3-adrenergic activation transiently recruits neutrophils into white adipose tissue through secreting a lipolysis-p38-dependent Leukotriene B4. Infiltrated neutrophils secrete Interleukin-1β, which suppresses lipolysis and limits excessive energy loss by inducing catecholamine resistance in adipocytes. Created in BioRender. Son, S. (2025) https://BioRender.com/dq8j6v7.

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