Extended Data Table 7 Association between self-reported medical disorders and ADNC

From: Prevalence of Alzheimer’s disease pathology in the community

  1. * Assessed only in HUNT3 aged 58 − 69 years. ¤ Assessed only in HUNT4 70+. pTau217 = tau phosphorylated at threonine 217, measured in picograms per millilitre (pg/mL); se = Linearized standard error. Alzheimer’s disease neuropathological changes (ADNC) are defined as plasma pTau217 concentration ≥ 0.63 pg/mL. Adjusted p-values (Bonferroni correction) from separate logistic regression models predicting ADNC positivity (pTau217 ≥ 0.63 pg/mL vs pTau217 < 0.63 pg/mL), each adjusted for age (1-year intervals), sex, APOE ε4 allele count, cognition, serum creatinine, and education level. All models were re-run after excluding participants in the intermediate range (0.40–0.63 pg/mL), redefining the outcome as pTau217 ≥ 0.63 pg/mL vs. pTau217 < 0.40 pg/mL. The results remained unchanged, with no significant differences in ADNC positivity between participants with and without the self-reported medical condition for any of the disorders assessed.
Back to article page