Extended Data Fig. 3: Clinical xenograft histopathology.
From: Physiology and immunology of a pig-to-human decedent kidney xenotransplant
Xenograft biopsies were obtained post-reperfusion and on post-operative days (POD) 10, 14, 21, 28, 33, 45, 49, 56, and 61. The first two columns display hematoxylin and eosin-stained biopsy sections illustrating the glomerular and tubulointerstitial (TI) compartments. Images were captured at 20x magnification. Additionally, deposition of IgG, IgM, IgA, C1q, C3, and C4d was assessed by immunofluorescence on biopsy timepoints with adequate tissue. All immunofluorescence images display glomeruli, except the C4d column, which displays the TI. (Supplementary Table S2).
