Extended Data Fig. 4: Comparison of the dynamics between sidechain and backbone in RHP-P1.

a, Average segmental root-mean-square fluctuation (RMSF) of nine RHP-P1 sequences (blue: combined backbone and sidechain RMSF, green: sidechain only RMSF, orange: backbone only RMSF). RMSF of SEQ10 is shown in Fig. 2a. RMSF is plotted as a function of segment position along a representative RHP-P1 chain based on MD simulation. The HLB value of each monomer was also shown on the same plot (red, left axis). Error bars represent the standard errors calculated across the ten conformations. Corresponding sequence is labeled in each plot, and the sequences can be found in Extended Data Fig. 2a. b, Linear regression between average segmental root-mean-square fluctuation (RMSF) and HLB value of each monomer in RHP-P1 shows positive correlation. Left: combined backbone and sidechain RMSF, Middle: backbone only RMSF, Right: backbone only RMSF.