Extended Data Fig. 7: Albumin deficiency compromises serum FFA composition and increases susceptibility to mucormycosis.
From: Albumin orchestrates a natural host defence mechanism against mucormycosis
a–b, Histopathology and cumulative hyphal counts of lungs from neutropenic Alb+/+ and Alb−/− mice infected with A. fumigatus or R. delemar (n = 4–6 mice). Data are mean ± s.d., two-sided Mann–Whitney test. Scale bar, 100 µm. c, Cell damage of A549 cells treated with mucoricin ± 4.5 g dl−1 FFA-free BSA (n = 14 mucoricin plus BSA, n = 15 mucoricin alone). Data are mean ± s.d. ***p = 0.0004, Mann–Whitney test. d, Serum non-oxidized/oxidized FFA concentrations in uninfected and infected Alb+/+ vs Alb−/− mice (n = 6). One-way ANOVA with Dunn’s test. e–f, Heatmaps of serum FFAs and free oxylipins (n = 10 mice, Wilcoxon rank sum test). g, Proposed model of albumin in host defence during Mucorales infection. Created with BioRender.com.
