Extended Data Fig. 6: The interfaces between D1R and GEMs.

a-c, The interactions between D1R and \(\text{GE}{\text{M}}_{\text{anchor}}^{\text{TM}1/2/4}\). a, The interaction surface. b, Analysis of hydrophobic and hydrophilic properties of interface residues. c, Detailed view showing residues and side chains at the \(\text{GE}{\text{M}}_{\text{anchor}}^{\text{TM}1/2/4}\)-D1R interface. d-f, The interactions between D1R and \(\text{GE}{\text{M}}_{\text{BAM}}^{\text{TM}3/4/5}\). d, The interaction surface. e, Analysis of hydrophobic and hydrophilic properties of interface residues. f, Detailed view showing residues and side chains at the \(\text{GE}{\text{M}}_{\text{BAM}}^{\text{TM}3/4/5}\)-D1R interface. g-i, The interactions between D1R and \(\text{GE}{\text{M}}_{\text{NAM}}^{\text{TM}5/6/7}\). g, The interaction surface. h, Analysis of hydrophobic and hydrophilic properties of interface residues. i, Detailed view showing residues and side chains at the \(\text{GE}{\text{M}}_{\text{NAM}}^{\text{TM}5/6/7}\)-D1R interface. j-l, The interactions between D1R and \(\text{GE}{\text{M}}_{\text{ago}-\text{PAM}}^{\text{TM}5/6/7}\). j, The interaction surface. k, Analysis of hydrophobic and hydrophilic properties of interface residues. l, Detailed view showing residues and side chains at the \(\text{GE}{\text{M}}_{\text{ago}-\text{PAM}}^{\text{TM}5/6/7}\)-D1R interface.