Extended Data Fig. 3: AlphaFold3 (AF3) predicted representative GEMs in the final iteration, bound to dopamine D1 receptor. | Nature

Extended Data Fig. 3: AlphaFold3 (AF3) predicted representative GEMs in the final iteration, bound to dopamine D1 receptor.

From: De novo design of GPCR exoframe modulators

Extended Data Fig. 3

a, Five structures predicted for each GEM, colored by pLDDT, with ipTM scores reported by AF3. The active state prediction included the Gαs sequence. b, Predicted aligned error plot reported by AF3. Red rectangle highlights the GEM-related sub-matrix.

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