Extended Data Fig. 4: Changes in blood pressure and pulse rate over time.

a. Change from baseline in SBP over time under the efficacy estimand. b. Change from baseline in DBP over time under the efficacy estimand. For a and b, symbols and error bars are LS means and 95% CI, and numbers are LS mean changes at week 24, from an MMRM analysis, mITT population. At week 24, n = 89 in the mazdutide 4 mg group, n = 86 in the mazdutide 6 mg group, and n = 82 in the placebo group had blood pressure measures. c. Change from baseline in pulse rate over time. Data are observed means and standard errors from descriptive analyses of the mITT population. n = 93 in the mazdutide 4 mg group, n = 96 in the mazdutide 6 mg group, and n = 103 in the placebo group had pulse rate measures. DBP=diastolic blood pressure. LS=least squares. mITT=modified intent-to-treat. MMRM=mixed model repeated measures. SBP=systolic blood pressure. CI=confidence interval. min=minute. *Nominal p < 0.05, **nominal p < 0.01 versus placebo. All p values were two-sided.