Extended Data Fig. 5: Replication within and across populations.
From: A cross-population compendium of gene–environment interactions
a–b, Replication statuses of G×E loci other than the ALDH2 locus (a) and the ALDH2 locus (b). Only interactions with at least one nominally significant replication (PG×E < 0.05) are shown. EUR, the European population; EAS, the East Asian population; AFR, the African population; AMR, the American population. c–f, The eGFR distributions across rs77924615 genotypes (the UMOD locus) and age in UKB1 (c), UKB2 (d), BBJ1 (e), and BBJ2 (f), as a representative example of cross-population shared G×E interaction. Dots, 5,000 randomly sampled individuals per genotype; lines, regression lines using all participants. g and h, Minor allele frequencies (MAF) of the lead variants (g) and environmental distributions (h) in UKB1 and BBJ1. In g, cross-population shared loci are marked with crosses and labelled by nearest genes. Solid gray lines represent x = 0, y = 0, and y = x. i, Number of G×E loci detected with PG×E less than 5.0×10−8 in randomly subsampled participants in UKB1 and BBJ1. Subsample sizes: 10, 50, 100, 150, and 200 thousand in UKB1; 10, 50, and 80 thousand in BBJ1. Full-cohort results are also shown (Nmean = 253,773 in UKB1 and 133,117 in BBJ1).
