Fig. 4: Genome-wide properties of G×E interactions.
From: A cross-population compendium of gene–environment interactions
a, Overview of PGS construction and evaluation of within-population prediction accuracy and cross-population portability. b,c, Examples of within-population prediction accuracy (R2): PP in UKB stratified by age (b) and uric acid in BBJ stratified by drinking status (c). Asterisks represent FDR < 0.05. d, BMI distribution stratified by G×E-PGS, and that from marginal PGS. Boxplots show median, quartiles and 1.5× interquartile range whiskers. N = 30,683 and 40,226 for male and female participants, respectively. e, UMAP of the Tabula Sapiens scRNA-seq data. We used the 10x Genomics subset and subsampled 100 cells per tissue–anatomy–cell type combination (Methods). Cell types defined in the original study. f,g, Single-cell associations with PP genetics in the younger (f) and older (g) groups. h, UMAP of the monkey artery scRNA-seq data. Cell types defined in the original study. i, Difference in single-cell associations between the older and younger groups.
