Fig. 5: Sexual dimorphism in lipid metabolites.
From: A cross-population compendium of gene–environment interactions
a, P values of marginal effects and G×E interactions for metabolites in five representative loci (from left to right: UGT2B17, CETP, TNFAIP8, CPS1 and TRIB1), estimated by two-sided linear regression. Triangles denote P < 1.0 × 10−50 (see Extended Data Fig. 10 for all 15 loci with genome-wide significant G×E interactions). LDL_TG_pct, triglycerides to total lipids in LDL percentage. b, Effect sizes of rs12720908 (the CETP locus) on LDL_TG_pct in UKB1, stratified by sex and age (see Supplementary Table 31 for sample sizes). c, Hazard ratios of LDL_TG_pct on all-cause and CAD-caused mortality in UKB1, stratified by sex and statin medication at registration (see Supplementary Table 32 for sample sizes). In b and c, data are presented as estimated values with 95% CI.
