Extended Data Fig. 2: Cryo-EM maps of MOR–Gi bound to MP, DAMGO and LFT in the baseline, GTP-primed, G-ACT-1, G-ACT-2 and G-ACT-3 states. | Nature

Extended Data Fig. 2: Cryo-EM maps of MOR–Gi bound to MP, DAMGO and LFT in the baseline, GTP-primed, G-ACT-1, G-ACT-2 and G-ACT-3 states.

From: Non-equilibrium snapshots of ligand efficacy at the μ-opioid receptor

Extended Data Fig. 2: Cryo-EM maps of MOR–Gi bound to MP, DAMGO and LFT in the baseline, GTP-primed, G-ACT-1, G-ACT-2 and G-ACT-3 states.

a, Maps for the nucleotide-free state, each of the consensus refinements of the three main ensembles of states for the GTP-bound state, and the 3DVA-separated states of the G-ACT-2/3 ensemble with each of the three ligands. G-ACT-3* corresponds to G-ACT-3 for MP and DAMGO, and G-ACT-2′ for LFT. b, Additional maps generated in this work with local refinement and/or additional 3DVA/3D classification.

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