Extended Data Fig. 9: G-ECD neutralizing antibody reverses established MASH progression and improves systemic metabolism.
(a to j) Mice are the same as described in Fig. 5h–n. BW (a), food intake (b), histological evaluation (c), serum AST and ALT (d), fat mass/BW and lean mass/BW ratios (e), weights of eWAT, ingWAT, and BAT, and their BW ratios (f), serum TG and TC (g), and blood glucose (h) (ND n = 10; 4 months n = 8; IgG n = 8; G-ECD Ab n = 8 mice). GTT and ITT (n = 4 mice per group) (i) and energy expenditure (n = 7 mice per group) (j). Data are presented as mean ± SEM (a, c-j). Unpaired two-tailed Student’s t-test (a, i, j) and one-way ANOVA with Tukey’s multiple-comparison test (c-h).
