Extended Data Fig. 7: IL-2-TGF-β co-agonists establish immune tolerance to suppress OVA-induced airway inflammation.

a–f, Therapeutic effect of TGM1–IL-2 in establishing tolerance to suppress OVA-induced airway inflammation (Mock, n = 4 mice; treatment groups, n = 7 mice/group). a, Quantification of serum toal IgE levels. b, Quantification of the numbers of the indicated cell populations in the lung and BALF. c, Representative flow cytometry plots and quantification of Foxp3⁺ and Rorγt⁺Foxp3⁺ OT-II cell frequencies and numbers in spleen. d, Representative flow cytometry plots and quantification of CD25⁺Foxp3⁺ and IL-10⁺Foxp3⁺ OT-II cell frequencies and numbers in LDLNs. e, Representative flow cytometry plots and quantification of ICOS⁺Foxp3⁺, CD103⁺Foxp3⁺, and CD39⁺Foxp3⁺ OT-II cell frequencies in LDLNs. f, Quantification of Gata3⁺Foxp3^- OT-II cell frequencies in LDLNs. Data are presented as mean ± s.e.m. The data in a–f are representative of two independent experiments. The statistics were obtained by one-way ANOVA coupled with Dunnett’s multiple-comparisons test (a–f).

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