Extended Data Fig. 10: Gene expression signatures defining distinct cell clusters revealed by scRNA-seq analysis. | Nature

Extended Data Fig. 10: Gene expression signatures defining distinct cell clusters revealed by scRNA-seq analysis.

From: Facile induction of immune tolerance by an interleukin-2–TGFβ surrogate agonist

Extended Data Fig. 10: Gene expression signatures defining distinct cell clusters revealed by scRNA-seq analysis.

a, Heatmap showing top 20 DEGs across distinct cell clusters. b–d, Violin (b), UMAP (c) and bubble plots (d) showing expression of selected genes across the indicated samples and clusters. e, Histogram showing the top 20 Gene Ontology (GO) pathways enriched among upregulated DEGs between the Ki-67+ pTreg cell cluster and the pTreg cell cluster, based on Metascape analysis (https://metascape.org). f, UMAP plots showing the indicated signature scores across clusters. g, UMAP plots showing the distribution of endogenous Foxp3-GFP+ CD4+ T cells from the indicated groups across distinct cell clusters.

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