Extended Data Fig. 11: pTregs induced by IL-2-TGF-β co-agonists in vivo exhibit effector and colonic Treg features. | Nature

Extended Data Fig. 11: pTregs induced by IL-2-TGF-β co-agonists in vivo exhibit effector and colonic Treg features.

From: Facile induction of immune tolerance by an interleukin-2–TGFβ surrogate agonist

Extended Data Fig. 11: pTregs induced by IL-2-TGF-β co-agonists in vivo exhibit effector and colonic Treg features.

a, Violin plots showing expression levels of TGF-β– (GEO, GSE264451), IL-2– (GEO, GSE162928), and STAT5-upregulated (GEO, GSE84553) gene sets across the indicated samples and clusters. b–d, UMAP (b) and violin plots (c and d) showing expression levels of activated Treg (GEO, GSE149674) and terminal effector Treg signature gene sets across the indicated samples and clusters. e, Violin plots showing expression levels of the colonic Treg signature gene set (ArrayExpress, E-MTAB-7311) across the indicated samples and clusters. f, UMAP plot showing expression levels of the colonic Rorγt+ Treg signature gene set across clusters. The statistics were obtained by unpaired Welch’s t-test (two-tailed) (d).

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