Extended Data Fig. 9: ZBTB18 Enhances Robo1 E1 Activity through Direct Binding.
From: Adaptive evolution of gene regulatory networks in mammalian neocortex
a) Line graphs showing the H3K27ac peaks from, Arpp21-Gfp+ cells (line 1 and 2), Fezf2-Gfp+ cells (line 3 and 4), from PCD 14.5, and PD 0 forebrain DNaseI Hypersensitivity tracks (DHS) by Digital DNaseI from ENCODE, (line 5 and 6, respectively) and mammal conservation as reference (line 7), ZBTB18-HA ChIP-seq peaks from mouse (line 8), H3K27ac peaks from fetal dlPFC (line 9), gene locus in mice (line 10) H3K27ac peaks collapsed together in the Arpp21-Gfp + IT neurons and Fezf2-Gfp + ET neurons (line 11) and H3K27ac peaks from E17 chicken dorsal pallium (12) at the genomic locus of Robo1. The regions detected by H3K27ac and ZBTB18- ChIP seq are in light beige color.
