Extended Data Fig. 3: Association of thymic health with progression-free and overall survival in patients with NSCLC in sex and age subgroups.

Cox proportional hazards models of PFS and OS of the Harvard-NSCLC cohort in subgroups according to a, sex with adjustments for age, ECOG performance status, and histologic subtype, b, age split at 65 years with adjustments for sex, ECOG performance status, and histologic subtype. a,b, Cox proportional hazards regression was used to estimate HRs. In the forest plots, the centre of each box represents the estimated hazard ratio, and the whiskers denote the corresponding 95% CI; shaded box size is for visualization only and does not encode statistical weight. The overall contribution of thymic health to multivariable models was evaluated using likelihood ratio tests (χ² tests) comparing full models with nested models excluding thymic health (type III test, two-sided) with no adjustments for multiple comparisons. GTE, greater than or equal to; LT, less than.