Extended Data Fig. 7: Unsupervised integration of PFA tumour cells and the mouse glial lineage.
From: Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma
a, UMAP visualization of PFA tumour clusters following RPCA integration with glial lineage. b, UMAP visualization of glial lineage clusters following RPCA integration with PFA tumours. c, Distribution of original PFA tumour and mouse glial lineage cell types across integrated clusters. d, Top 3 marker genes per cluster by average log2FC in the integrated dataset. DEGs were assessed using the two-sided MAST test with Benjamini–Hochberg corrections for multiple comparisons (log2FC > 0.25, min.pct > 0.1, adjusted P < 0.05). e, Ridge plot visualization of integrated clusters across glial developmental pseudotime trajectory (Monocle 3). f, Pie visualization of glial lineage and PFA tumour proportions in integrated clusters. g, Pie visualization of glial lineage and PFA tumour proportions in integrated clusters by sex. h, Pie visualization of glial lineage cell-type proportions in integrated clusters. i, Pie visualization of PFA tumour cell-type proportions in integrated clusters.
