Fig. 2: Genetic evidence for a systemic landscape of abnormal sleep duration patterns compared to normal sleep duration.
From: Sleep chart of biological ageing clocks in middle and late life
a, The top lead SNP, the nearest gene and cytogenetic regions associated with short (4–6 h) and long (8–10 h) sleep duration compared with a normal sleep duration (6–8 h), with significant genomic loci identified using the genome-wide significance threshold (two-sided P < 5 × 10−8). b, MAGMA gene property analysis of tissue-specific expression across 54 GTEx v.8 tissues. Statistical significance was determined using FDR-adjusted P values (<0.05). acc., accumbens; ecto., ectocervix; endo., endocervix; exp., exposed; GE, gastroesophageal; oesoph., oesophagus. c, Genetic correlation estimates based on the LDSC between the two abnormal sleep duration patterns and 527 DEs from FinnGen and PGC (two-sided P < 0.05/527). The error bars represent the s.e. of the LDSC genetic correlation (rg) estimate. An interactive webpage is available (https://labs-laboratory.com/sleepchart/sleep_gc.html) to facilitate visualization. Sample sizes of the FinnGen and PGC DEs are presented in Supplementary Table 7. CPAP, continuous positive airway pressure; T2D, type 2 diabetes. The diagrams in b and c were created using images from the Noun Project and NIAID Visual & Medical Arts.
