Extended Data Fig. 1: Sleep Chart delineates U-shaped associations between sleep duration and 720 organ-specific imaging-derived phenotypes.
From: Sleep chart of biological ageing clocks in middle and late life
a) Sleep duration was associated with 720 organ-specific imaging-derived phenotypes (IDP; x-axis) using the GAM model. Non-grey coloured IDPs indicate significant associations after Bonferroni correction for multiple comparisons across all available IDPs (two-sided P < 0.05/720). The y-axis shows the effective degrees of freedom (EDF), quantifying the degree of nonlinearity for the U-shaped patterns, with representative proteins annotated for each organ. b) The EDF brain map displays the EDF values for significant signals associated with brain IDPs derived from T1-weighted MRI. c) The EDF brain map displays the EDF values for significant signals associated with brain IDPs derived from fractional anisotropy (FA) using diffusion MRI. d-j) Representative IDPs from various organ systems and tissues illustrate U-shaped associations with sleep duration. The solid curves depict estimated IDP, while shaded bands represent the 95% confidence interval (CI).
