Extended Data Fig. 6: Anti-CCR3 treatment have minimal influence on pregnancy outcomes, but reduced goblet cell induction in the small intestine.
From: Eosinophils drive intestinal remodelling and innate defence in reproduction
a, Left: images of fetus at ~E18.5 in isotype- or anti-CCR3-treated pregnant mice. Red arrows indicate absorbed fetus. Right: Bar plots showing fetal numbers; n = 4. b, Small intestinal length; Control (n = 3), Isotype (n = 6), α-CCR3 (n = 5). c, Villus length; Control (n = 3), Isotype (n = 6), α-CCR3 (n = 6). d, Dam and pup weight curves. e, Single-channel grey-scale images for the representative confocal images of villus-resident UEA1+ goblet cells. Scale bar = 70 μm. f, Single-channel grey-scale images for the representative confocal images of organoids derived from single Lgr5+ ISCs. Scale bar = 50 μm. Data are representative or pooled from at least two independent experiments. Each dot represents one individual mouse except for kinetic plot (d). Error bars represent mean ± SD. *P < 0.05 (one-way ANOVA).
